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  • Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)

Group of Comparative and Regenerative Neurobiology - NeuroCoRe

Reference of the Group:

GIUV2026-041

 
Description of research activity:
Myelination was a key evolutionary event for the development of large and highly complex nervous systems in jawed vertebrates. Myelin, a lipid-rich membranous structure, enables the saltatory conduction of action potentials along axons and additionally provides metabolic support to axons through the supply of essential metabolites. Loss of myelin, as well as alterations in its composition and organization can compromise axonal integrity and trigger neurodegenerative processes. Myelin abnormalities are a common feature of numerous central nervous system (CNS) pathologies, including leukodystrophies, spinal cord injuries, multiple sclerosis (MS) and other inflammatory demyelinating disorders of the CNS, periventricular leukomalacia, as well as several classical neurodegenerative diseases such as Alzheimer's disease. In this context, therapeutic approaches to these disorders should necessarily incorporate strategies aimed at preserving and/or regenerating myelin. Our research focuses on: 1. Understanding the molecular and cellular mechanisms that regulate myelin generation, maintenance, and regeneration in animal models, with a particular emphasis on oligodendroglial energy...Myelination was a key evolutionary event for the development of large and highly complex nervous systems in jawed vertebrates. Myelin, a lipid-rich membranous structure, enables the saltatory conduction of action potentials along axons and additionally provides metabolic support to axons through the supply of essential metabolites. Loss of myelin, as well as alterations in its composition and organization can compromise axonal integrity and trigger neurodegenerative processes. Myelin abnormalities are a common feature of numerous central nervous system (CNS) pathologies, including leukodystrophies, spinal cord injuries, multiple sclerosis (MS) and other inflammatory demyelinating disorders of the CNS, periventricular leukomalacia, as well as several classical neurodegenerative diseases such as Alzheimer's disease. In this context, therapeutic approaches to these disorders should necessarily incorporate strategies aimed at preserving and/or regenerating myelin. Our research focuses on: 1. Understanding the molecular and cellular mechanisms that regulate myelin generation, maintenance, and regeneration in animal models, with a particular emphasis on oligodendroglial energy metabolism, in order to identify novel therapeutic targets. 2. Developing therapeutic strategies aimed at stimulating myelin regeneration and maintenance in multiple sclerosis and other neurodegenerative diseases.
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Web:

No determinada

 
Scientific-technical goals:
  • Understanding the molecular and cellular mechanisms that regulate myelin generation, maintenance, and regeneration in animal models, with a particular emphasis on oligodendroglial energy metabolism, in order to identify novel therapeutic targets.
  • Develop therapeutic strategies aimed at stimulating myelin regeneration and maintenance in multiple sclerosis and other neurodegenerative diseases.
 
Research lines:
  • Myelin evolution and pathologies.Myelin is a multilamellar membrane -rich structure that ensheathes the axons. We are interested in understanding how mechanisms of axo-glial communication as well as the structure and compaction of myelin evolved across different invertebrate and vertebrate species. We are also investigating myelin alterations in different models of neurodegenerative diseases
  • Therapeutic strategies for myelin regeneration in neurodegenerative diseases.Myelin accelerates axonal conduction and protects axons from degeneration. We are developing potential therapeutic strategies to regenerate myelin in neurodegenerative diseases, particularly in multiple sclerosis. We are particularly interested in strategies focused on alleviating metabolic dysfunction, an important feature common to all neurodegenerative pathologies.
  • Ageing and myelin dysfunction.Ageing significantly decreases the efficiency of myelin regeneration. We are studying the mechanisms underlying metabolic dysfunction of oligodendroglial cells that develops during ageing and interventions that might alleviate this dysfunction thus improve myelin regeneration and maintenance to achieve neuroprotection.
 
Group members:
Name Nature of participation Entity Description
VANJA TEPAVCEVIC MANDICDirectorUniversitat de València
Research team
LUNA MORA HUERTAMemberUniversitat de València
MIGUEL FERNANDEZ POLOMemberUniversitat de València
FRANCISCO GARCIA GARCIACollaboratorFundacion de la Comunidad Valenciana Centro de Investigacion Principe FelipeResearcher
LUCAS BAREA MOYACollaboratorInstituto de Investigación Sanitaria La FeResearcher
CATALINA RAVAZZANO BRAVOCollaboratorUniversitat de València
 
CNAE:
  • -
  • -
 
Associated structure:
  • Cavanilles Institute Biodiversity and Evolut. Biol. (ICBBE)
 
Keywords:
  • MYELIN
  • OLIGODENDROCYTES
  • MULTIPLE SCLEROSIS
  • METABOLISM
  • COGNITIVE RESERVE
  • EVOLUTION
  • AGING
  • REGENERATION
  • GENE THERAPY
  • REMYELINATION