GIUV2026-026

The research activity of the enzymatic biomimetics research group (Greben) focuses on the development of systems capable of mimicking the catalytic behavior of enzymes whose activity is of biological or environmental interest. This group of enzymes includes antioxidants such as superoxide dismutase and the catalase and peroxidase families, as well as other proteins such as carbonic anhydrase. This objective is pursued on several fronts, including the synthesis of mimetics (coordination complexes and nanostructured systems), their characterization and speciation under physiological conditions, the analysis of their catalytic activity, and the study of their reaction mechanism. To this end, techniques such as organic synthesis, spectroscopy and spectrophotometry, potentiometry, and electrochemistry are used. Likewise, an important part of the work consists of the analysis, through computational modeling (DFT and molecular dynamics), of the developed systems and their mechanism of activity.

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• Desarrollo de sistemas biomiméticos con capacidad de imitar el comportamiento catalítico de enzimas con relevancia biológica o medioambiental.

• Development of enzyme mimetics with antioxidant activity.Development and study of the mechanism of action of discrete and nanostructured compounds in order to mimic the catalytic capacity of enzymes with antioxidant activity such as superoxide dismutase and catalase.

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• Physical Chemistry