Prevention and treatment of the diabetic foot syndrome - PERSIST

Reference of the Group:

GIUV2025-657

 
Description of research activity:
According to the World Health Organization, Diabetic Foot Syndrome is characterized as "ulceration of the foot (distal ankle and including the ankle) associated with neuropathy and varying degrees of ischemia and infection." In Spain, approximately 1,500,000 individuals are afflicted with diabetic foot disease, a condition characterized by the presence of diabetic neuropathy, peripheral arterial disease, and foot ulcers associated with diabetes. Spain has the fourth-highest rate of diabetes-related amputations in Europe, with the primary causes of these amputations being the delayed referral of patients to multidisciplinary diabetic foot units and the delayed diagnosis of peripheral arterial disease. The mortality associated with the diabetic foot should not be underestimated. According to the study published by Armstrong in 2020, the mortality rate from diabetic foot complications five years after diagnosis is three times that of breast cancer in the presence of a foot ulcer and six times higher when associated with total foot amputations. According to data from the Diabetes Atlas, a person with diabetes suffers a partial or total amputation every 20 seconds worldwide.The...According to the World Health Organization, Diabetic Foot Syndrome is characterized as "ulceration of the foot (distal ankle and including the ankle) associated with neuropathy and varying degrees of ischemia and infection." In Spain, approximately 1,500,000 individuals are afflicted with diabetic foot disease, a condition characterized by the presence of diabetic neuropathy, peripheral arterial disease, and foot ulcers associated with diabetes. Spain has the fourth-highest rate of diabetes-related amputations in Europe, with the primary causes of these amputations being the delayed referral of patients to multidisciplinary diabetic foot units and the delayed diagnosis of peripheral arterial disease. The mortality associated with the diabetic foot should not be underestimated. According to the study published by Armstrong in 2020, the mortality rate from diabetic foot complications five years after diagnosis is three times that of breast cancer in the presence of a foot ulcer and six times higher when associated with total foot amputations. According to data from the Diabetes Atlas, a person with diabetes suffers a partial or total amputation every 20 seconds worldwide.The Research Group on the Prevention and Treatment of Diabetic Foot Syndrome (PERSIST) is a multidisciplinary group with a translational purpose. The acronym of the group indicates the necessity to persist in the advancement of early diagnosis and, once lesions appear, in the study of the most efficacious therapeutic options for an unresolved health problem, such as Diabetic Foot Syndrome. The institution is composed of clinical and basic researchers, and its personnel are assigned to the University of Valencia, the European University of Valencia, the Polytechnic University of Valencia, the University Hospital and Polyclinic of La Fe, and the Institute for Health Research La Fe. From a clinical perspective, it convenes representatives from podiatry, nursing, and vascular surgery, integrating research, clinical, and teaching dedication in the domain of diabetic foot care. Within the domain of fundamental science, there exists a cadre of researchers specializing in biochemistry, biotechnology, and physics. These experts are engaged in the study of biomarkers and therapeutic targets that have clinical applications in the context of diabetic foot syndrome. The primary research areas of the group are as follows:Early diagnosis of Diabetic Foot Syndrome; Prediction of progression of Diabetic Foot Syndrome; Peripheral Arterial Disease, Neuropathy and Infection in Diabetic Foot Syndrome; Physical activity in Diabetic Foot Syndrome; Tissue response in local, physical and surgical treatments of ulcers in Diabetic Foot Syndrome; Frailty and Diabetic Foot Syndrome; Offloading and footwear therapy in Diabetic Foot Syndrome and Pressure Injuries in Diabetic Foot Syndrome.
[Read more][Hide]
 
Web:

No Determinada

 
Scientific-technical goals:
  • Estudio de las bases fisiopatologicas del Sindrome del pie diabetico: evaluacion de biomarcadores y determinacion de su valor pronostico
  • Estudio de los cambios biomecanicos precoces en el Sindrome del pie diabetico
  • Respuesta fisiologica de los tejidos en el pie en la enfermedad arterial periferica, neuropatia e infeccion.
  • Actividad fisica compatible con el Sindrome del Pie Diabetico.
  • Influencia del Sindrome del Pie Diabetico en la calidad de vida, la fragilidad y las lesiones por presion en las personas ancianas
 
Research lines:
  • Early diagnosis of the diabetic foot syndrome.This line of research has the following objectives: the search for biomarkers (chemical and physical) and biomechanical factors that enable early diagnosis of diabetic foot lesions.
  • Prediction of diabetic foot syndrome progression.This line of research aims to study biomarkers (chemical and physical) that enable objective stratification of the clinical progression of this syndrome.
  • Peripheral artery disease, neuropathy, and infection in the diabetic foot syndrome..This line of research aims to study the biochemical, biophysical and clinical relationships between the three fundamental entities involved in the development of ulcers and amputations in the diabetic foot.
  • Physical activity in patients with diabetic foot syndrome.This line of research aims to study the type and intensity of physical activity that allows for the control of diabetes mellitus and does not promote the development of diabetic foot lesions.
  • Tissue Response to Local, Physical, and Surgical Treatments of Ulcers in the Diabetic Foot Syndrome..This line of research aims to study biomarkers (chemical and physical) that help determine the effectiveness of different treatments applied in clinical practice.
  • Fragility and diabetic foot syndrome.This line of research aims to study the relationships between these two entities in the elderly population.
  • Offloading and Shoe Therapy for the Diabetic Foot Syndrome..This line of research aims to study the physiological and biomechanical response of the foot to the application of orthotic devices used to reduce plantar pressure in diabetic foot syndrome.
  • Pressure Ulcers/Injuries and Diabetic Foot Syndrome.This line of research aims to study the relationships between these two pathologies in the context of elderly people with diabetes, both in terms of prevention and treatment.
 
Group members:
Name Nature of participation Entity Description
IVAN JULIAN ROCHINADirectorUniversitat de València
Research team
MARTA IZQUIERDO RENAUCollaboratorUniversitat de València
OMAR CAULI CollaboratorUniversitat de València
MARIA ISABEL GOMEZ GOMEZCollaboratorUniversitat Politècnica de Valènciaadjunct professor
DAVID PAJUELO GAMEZCollaboratorUNIVERSIDAD EUROPEA DE VALENCIApre-tenured lecturer
CRISTINA SOLANA MANRIQUECollaboratorUNIVERSIDAD EUROPEA DE VALENCIAadjunct professor
EMMA PLANA ANDANICollaboratorINSTITUTO DE INVESTIGACION SANITARIA LA FE (VALENCIA)researcher
RAMÓN DURÁ MORACollaboratorHospital Universitari i Politècnic La Fenurse
VICENTE MOLINA NÁCHERCollaboratorHospital Universitari i Politècnic La Fephisician
JOSE DAVID PIÑEIRO RAMOSCollaboratorUNIVERSIDAD EUROPEA DE VALENCIApre-tenured lecturer
 
CNAE:
  • -
  • -
  • -
  • -
  • -
  • -
 
Associated structure:
  • Nursing