GIUV2025-634
Our research explores the neuroscience of behaviour in social interactions and pain processing, with a special focus on the emergence of social behaviours. We investigate the genetic and epigenetic factors that shape these behaviours, with particular attention to neurodevelopmental disorders with a genetic basis, such as Williams syndrome, Rett syndrome, and autism spectrum disorders. Using animal models, especially zebrafish (Danio rerio) and mice (Mus musculus), our goal is to better understand the underlying mechanisms that drive social and pain-related behaviours, with the aim of advancing therapeutic strategies for these conditions. Through our research, we aim to:
1. Examine the coexistence and interaction between social dysfunction and pain sensitivity in neurodevelopmental disorders, identifying potential biomarkers or molecular pathways that link these behavioural changes.
2. Discover the specific genetic and epigenetic factors influencing social and pain behaviours, with a special focus on their role in neurodevelopmental disorders such as Williams syndrome, Rett syndrome, and autism spectrum disorders.
3. Investigate how specific genetic mutations contribute to the...Our research explores the neuroscience of behaviour in social interactions and pain processing, with a special focus on the emergence of social behaviours. We investigate the genetic and epigenetic factors that shape these behaviours, with particular attention to neurodevelopmental disorders with a genetic basis, such as Williams syndrome, Rett syndrome, and autism spectrum disorders. Using animal models, especially zebrafish (Danio rerio) and mice (Mus musculus), our goal is to better understand the underlying mechanisms that drive social and pain-related behaviours, with the aim of advancing therapeutic strategies for these conditions. Through our research, we aim to:
1. Examine the coexistence and interaction between social dysfunction and pain sensitivity in neurodevelopmental disorders, identifying potential biomarkers or molecular pathways that link these behavioural changes.
2. Discover the specific genetic and epigenetic factors influencing social and pain behaviours, with a special focus on their role in neurodevelopmental disorders such as Williams syndrome, Rett syndrome, and autism spectrum disorders.
3. Investigate how specific genetic mutations contribute to the development and alteration of social behaviours, using animal models like zebrafish and mice to model neurodevelopmental conditions.
4. Refine zebrafish and mouse models to study social and pain-related behaviours in the context of genetic neurodevelopmental disorders, ensuring they accurately represent human pathologies such as Williams syndrome, and autism spectrum disorders.
5. Explore how epigenetic mechanisms (e.g., DNA methylation, histone modifications) regulate social and pain behaviours in genetically altered animal models, identifying potential therapeutic targets for intervention.
6) Practical training for researchers who wish to obtain the title for the use of research animals, especially fish.
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- Investigar la relacio entre les patologies dels comportaments socials i del dolor
- Caracteritzar l'impacte de les mutacions genetiques en l'emergencia dels comportaments socials
- Identificar els moduladors genetics i epigenetics dels comportaments socials i del dolor
- Desenvolupar i validar models animals per a trastorns del neurodesenvolupament
- Social and Pain Behaviours: Genetic and Epigenetic Insights.Our research explores the neuroscience of social interactions and pain processing, with a particular focus on the emergence of social behaviours. We investigate the genetic and epigenetic factors that shape these behaviours, paying particular attention to neurodevelopmental disorders with a genetic basis, such as Williams syndrome, Rett syndrome and autism spectrum disorders.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| JOSE VICENTE TORRES PEREZ | Director | Universitat de València | |
| Research team | |||
| MARIA ABELLAN ALVARO | Collaborator | Universitat de València | |
| MARIA ABELLAN ALVARO | Collaborator | Universitat Jaume I | researcher |
| ISTVAN NAGY | Collaborator | Imperial College London | professor |
| CARAOLINE H BRENNAN | Collaborator | Queen Mary University of London | full university professor |
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- Cellular Biology, Functional Biology and Physical Anthropol.
