The UV research groups (GIUV) are regulated in the 1st chapter of the Regulation ACGUV48/2013, which explains the procedure for creating new research structures. They are basic research and organizational structures that result from the voluntary association of researchers that share objectives, facilities, resources and common lines of research. These researchers are also committed to the consolidation and stability of their activity, work in groups and the capability to achieve a sustainable funding.
The research groups included in the previously mentioned Regulation are registered in the Register of Research Structures of the Universitat de València (REIUV), managed by the Office of the Vice-principal for Research. The basic information of these organisms can be found in this website.
Participants
Data related to research groups featured in various information dissemination channels shall not, under any circumstances, imply a statement or commitment regarding the employment or academic affiliation of individuals associated with the Universitat de València. Their inclusion is solely the responsibility of the group directors. Updates will be made upon request from interested parties.
- Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)
Reference of the Group:
Description of research activity: The group focuses its efforts on unravelling the pathophysiological mechanisms of rare diseases, mainly progeroid processes and neuromuscular diseases. This research helps to understand the process of organic ageing. We have provided a new animal model of Charcot-Marie-Tooth disease and contributed to a better understanding of the relationship between oxidative stress and gene regulation mechanisms modulated by epigenetic factors. Down's syndrome, the disease that most frequently develops mental deficiency, has also been approached from the perspective of changes in cell turnover processes, contributing to elucidating its pathophysiology. In Lafora disease, which has a poor prognosis, we have described the presence of oxidative stress and the lack of antioxidant defence.
Web:
Scientific-technical goals: - Estudio del estres oxidativo y la regulacion epigenetica inducida en las enfermedades raras
Research lines: - Pathophysiology of Fanconi anemia and Friedreich ataxia.Pathophysiology of Fanconi's anaemia and Friedreich's ataxia.
- Study of oxidative stress and mechanisms of DNA repair in different progeroid syndromes and genodermatosis.Study of oxidative stress and DNA repair mechanisms in different progeroid syndromes and genodermatoses.
- Epigenetic regulation in the physiopathology of rare diseases.Study of oxidative stress and DNA repair mechanisms in different progeroid syndromes and genodermatoses.
Group members:
CNAE:
Associated structure: 
