The UV research groups (GIUV) are regulated in the 1st chapter of the Regulation ACGUV48/2013, which explains the procedure for creating new research structures. They are basic research and organizational structures that result from the voluntary association of researchers that share objectives, facilities, resources and common lines of research. These researchers are also committed to the consolidation and stability of their activity, work in groups and the capability to achieve a sustainable funding.
The research groups included in the previously mentioned Regulation are registered in the Register of Research Structures of the Universitat de València (REIUV), managed by the Office of the Vice-principal for Research. The basic information of these organisms can be found in this website.
Participants
Data related to research groups featured in various information dissemination channels shall not, under any circumstances, imply a statement or commitment regarding the employment or academic affiliation of individuals associated with the Universitat de València. Their inclusion is solely the responsibility of the group directors. Updates will be made upon request from interested parties.
- Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)
Reference of the Group:
Description of research activity: The Laboratory of Molecular Ageing in Chronic Diseases is focused on understanding the molecular mechanisms that play a key role in the relationship between ageing and chronic diseases. To this end, we concentrate on studying the role of cellular heterogeneity in organ and tissue function, predicting accelerated ageing in chronic conditions, and developing in vitro models to mimic ageing in a Petri dish.
Advances in genomic, epigenomic, and transcriptomic technologies are ushering in a new era for understanding the molecular mechanisms underlying organismal ageing. Through this approach, we aim to accelerate the development of anti-ageing interventions to prevent or reduce the incidence of age-related diseases.
We develop novel omics and single-cell methodologies, with a focus on metabolic diseases, by analysing both liquid and solid samples from various species. We are particularly interested in the translational applications of our methodologies, with special emphasis on longitudinal cohorts, including paediatric and elderly donors.
Web:
Scientific-technical goals: - El objetivo principal es entender el papel de la heterogeneidad celular en la funcion de organos y tejidos.
Research lines: - Cellular heterogeneity and susceptibility to chronic diseases.We investigate how cellular heterogeneity affects tissue function and whether variability between cells increases susceptibility to disease.
- Accelerated ageing in young individuals.Lifestyle, dietary interventions and chronic diseases have been shown to accelerate the ageing phenotype. Our goal is to dissect the genetic and epigenetic molecular signatures associated with accelerated ageing under different conditions.
- Crosstalk between ageing and epigenetics in chronic diseases.To better understand the precise molecular mechanisms that lead to cellular heterogeneity, we investigate the epigenetic profile and histone and DNA modifications in individual cells using single-cell multi-omic approaches.
- Modelled ageing in organoids.Our goal is to develop three-dimensional organoids that recapitulate the molecular characteristics of ageing in order to establish functional assays and evaluate therapeutic interventions against ageing.
Group members:
CNAE:
Associated structure: - Univ. Institute Biotechnology and Biomedicine (BIOTECMED)
