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Participants

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  • Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)

Research Group on Environmental Risk Assessment of Xenobiotics - GERAX

Reference of the Group:

GIUV2025-665

 
Description of research activity:
The objective of the Research Group on Environmental Risk Assessment of Xenobiotics is the study of synthetic substances (biocides, pesticides, drugs, nanoparticles, etc.) with (eco)toxicological effects on ecosystems as a whole and individually on the organisms that inhabit them. In recent years, the study of the effects of substances considered emerging or priority substances and of a new typology of compounds whose properties are not comparable to those of traditional substances, namely nanoparticles, has been of great interest. In this sense, GERAX approaches in an integral way the study of these substances in the environment evaluating the effects on the trophic chains and on the organisms individually in different environments (soils, continental and marine waters, sediments), applying standardized ecotoxicological bioassays (ISO and OECD), batteries of multi-trophic and microcosm bioassays; for this purpose it applies and develops (eco)toxicity bioassays based on the use of indicator organisms. Environmental risk assessment is performed in an integrated manner, understanding ecosystems as a set of complex but interrelated compartments. The group is an expert in the...The objective of the Research Group on Environmental Risk Assessment of Xenobiotics is the study of synthetic substances (biocides, pesticides, drugs, nanoparticles, etc.) with (eco)toxicological effects on ecosystems as a whole and individually on the organisms that inhabit them. In recent years, the study of the effects of substances considered emerging or priority substances and of a new typology of compounds whose properties are not comparable to those of traditional substances, namely nanoparticles, has been of great interest. In this sense, GERAX approaches in an integral way the study of these substances in the environment evaluating the effects on the trophic chains and on the organisms individually in different environments (soils, continental and marine waters, sediments), applying standardized ecotoxicological bioassays (ISO and OECD), batteries of multi-trophic and microcosm bioassays; for this purpose it applies and develops (eco)toxicity bioassays based on the use of indicator organisms. Environmental risk assessment is performed in an integrated manner, understanding ecosystems as a set of complex but interrelated compartments. The group is an expert in the assessment of soils contaminated by anthropogenic activities, especially industrial and mining activities, but also by the use of agrochemicals. The growing demand by the EU for the generation of alternative systems to animal experimentation has allowed GERAX to establish collaborations with other research groups and companies that develop computational models designed to predict the (eco)toxicological effect of chemical substances on a multitude of biological targets, in this sense, GERAX participates in the experimental validation of these models designed in silico. The monitoring of environmental pollutants and the study of the impacts on living beings is another important field of study for GERAX, where the experience in the study of mutagenicity, genotoxicity and cytotoxicity in in vivo and in vitro models has allowed to establish the health and environmental risk of these new generation substances.
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Web:

No Determinada

 
Scientific-technical goals:
  • Evaluar el Riesgo Ambiental de nueva sustancias quimicas con efectos perjudiciales para el medio ambiente desde un punto de vista integrado
 
Research lines:
  • Environmental Risk Assessment (ERA).Assessment of the impact of xenobiotics: biocides, pesticides, PFAS, pharmaceuticals, nanoparticles, nanoplastics and emerging pollutants in environmental matrices in accordance with European directives (REACH, BPR, CLP).
  • Environmental monitoring.Design and application of multitrophic batteries for monitoring toxicity in terrestrial and aquatic ecosystems, both continental and marine.
  • Computational (eco)toxicology.Experimental validation of models for predicting (eco)toxicological properties based on QSAR systems.
  • Environmental exposure assessment.Study of the toxic effect of exposure to xenobiotics on living beings (biomarkers, oxidative stress, mutagenicity, cytotoxicity and genotoxicity).
 
Group members:
Name Nature of participation Entity Description
OSCAR ENRIQUE ANDREU SANCHEZDirectorUniversitat de València
Research team
JESUS VICENTE DE JULIAN ORTIZCollaboratorUniversitat de València
JESUS MUÑOZ BERTOMEUCollaboratorUniversitat de València
EUGENIO GOMEZ MINGUETCollaboratorUniversitat de València
EULALIA MARÍA BELTRÁN RODRÍGUEZCollaboratorInstituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria - CSICtenured scientist
BORJA MERCADO CASARESCollaboratorUNIVERSIDAD EUROPEA DE VALENCIAprofessor
Mª VICTORIA PABLOS CHICollaboratorInstituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria - CSICtenured scientist
 
CNAE:
  • -
  • -
  • -
 
Associated structure:
  • Plant Biology