The UV research groups (GIUV) are regulated in the 1st chapter of the Regulation ACGUV48/2013, which explains the procedure for creating new research structures. They are basic research and organizational structures that result from the voluntary association of researchers that share objectives, facilities, resources and common lines of research. These researchers are also committed to the consolidation and stability of their activity, work in groups and the capability to achieve a sustainable funding.
The research groups included in the previously mentioned Regulation are registered in the Register of Research Structures of the Universitat de València (REIUV), managed by the Office of the Vice-principal for Research and Scientific Policies. The basic information of these organisms can be found in this website.
Participants
Data related to research groups featured in various information dissemination channels shall not, under any circumstances, imply a statement or commitment regarding the employment or academic affiliation of individuals associated with the Universitat de València. Their inclusion is solely the responsibility of the group directors. Updates will be made upon request from interested parties.
- Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)
Reference of the Group:
Description of research activity: Study of intercellular communications berween different organisms mediated by extracellular vesicles, including parasite-host, plant-pathogen, and plant-mammals.
Web:
Scientific-technical goals: - Our group has extensive experience in studying molecular interactions between parasitic helminths, hosts and their microbiota, using omics techniques (genomics, transcriptomics, and proteomics). Along these lines, we have identified, isolated, and characterized extracellular vesicles (EVs) in helminths, describing their cargo (proteins and small RNAs), and analyzed their role in parasite-host interactions. Our studies focus on the usefulness of these EVs in the control of helminth infections (diagnosis, vaccination, and treatment), and their potential applicability to other diseases.
Another line of research focuses on the study of plant EVs and their role in plant-pathogen interactions, specifically EVs present in phloem sap.
A complementary line of research addresses the characterization of nanovesicles from plants and food (plant tissues and food industry waste) and their potential biomedical applications. These studies analyze both, their direct application (using experimental models of pathologies with an inflammatory component), and their potential as vehicles for specific molecules with immunizing (vaccines) or therapeutic activity against helminthiasis and other diseases.
Research lines: - Characterization of extracellular vesicles and their components. Applications in health..Isolation and characterisation of extracellular vesicles (EVs) in different helminth parasites. Identification of molecules present in EVs. Analysis for the usefulness of EVs in helminthiasis control and other diseases (diagnosis, vaccination and treatment).
- Nanovesicles derived from food.Characterization of nanovesicles from plants and food (plant tissues and food industry waste) and their potential biomedical applications. These studies analyze both, their direct application (using experimental models of pathologies with an inflammatory component), and their potential as vehicles for specific molecules with immunizing (vaccines) or therapeutic activity against helminthiasis and other diseases.
- Role of extracellular vesicles from microbiota as mediators in host-parasite relationships.Our group works to advance in the understanding the molecular mechanisms involved in communication between parasites, their hosts, and the hosts' microbiota, with a particular focus on interactions mediated by extracellular vesicles. Unraveling how parasite-host-microbiota interactions work is fundamental to advancing our knowledge of the basic biology of parasites, generating knowledge that will allow us to develop innovative strategies for controlling parasitic diseases of medical and veterinary interest. Furthermore, given the ability of some helminths (parasitic worms) to modulate the host's immune system toward anti-inflammatory phenotypes, and the role of the gut microbiota in these processes, identifying and characterizing the bacterial mediators responsible for these effects aims to pave the way for the discovery of new active ingredients for the treatment of chronic inflammatory diseases, whose incidence in industrialized societies continues to rise.
Group members:
CNAE:
Associated structure: - Pharmacy, Pharmaceutical Technology and Parasitology
Keywords: - Autenticidad-Contaminantes-Análisis-Profiling-Foodomics-Calidad alimentaria-Seguridad alimentaria-Estimación de las ingestas-Evaluación del riesgo
- Microbiota
- FOOD SAFETY
- BIOAVAILABILITY
- EXOSOMES
- FOOD
- BIOACTIVE COMPOUNDS
- BIOACCESSIBILITY
- INFLAMMATORY DISEASES: HUMAN AND ANIMAL HEALTH
- HELMINTHIASIS
- EXTRACELLULAR VESICLES
- FUNCTIONAL FOODS
