GIUV2013-125
Chirality is a property related to the three-dimensional shape of molecules. Chiral molecules can exist in two forms (enantiomers) that are mirror images of each other. This subtle difference has tremendously important implications in chemistry, as two enantiomers can exhibit completely different or even opposite biological or pharmacological properties. Similarly, the mechanical, magnetic or electrical properties of many materials can vary completely depending on whether they are made up of a single enantiomer or mixtures of enantiomers. As a consequence of all this, there is a real need at both laboratory and industrial level for synthetic procedures that allow chiral compounds to be obtained selectively in a defined enantiomeric form. Among the different methodologies available for this purpose, those using chiral catalysts are the most suitable, as they allow minimising the consumption of chiral starting materials and reducing waste production, contributing to more efficient, more economical and more environmentally friendly chemical processes. In this context, the asymmetric catalysis group investigates the development of new chiral catalysts based on both metal complexes and...Chirality is a property related to the three-dimensional shape of molecules. Chiral molecules can exist in two forms (enantiomers) that are mirror images of each other. This subtle difference has tremendously important implications in chemistry, as two enantiomers can exhibit completely different or even opposite biological or pharmacological properties. Similarly, the mechanical, magnetic or electrical properties of many materials can vary completely depending on whether they are made up of a single enantiomer or mixtures of enantiomers. As a consequence of all this, there is a real need at both laboratory and industrial level for synthetic procedures that allow chiral compounds to be obtained selectively in a defined enantiomeric form. Among the different methodologies available for this purpose, those using chiral catalysts are the most suitable, as they allow minimising the consumption of chiral starting materials and reducing waste production, contributing to more efficient, more economical and more environmentally friendly chemical processes. In this context, the asymmetric catalysis group investigates the development of new chiral catalysts based on both metal complexes and organocatalysts and their application in various enantioselective C-C bond formation reactions aimed at the synthesis of enantiomerically enriched chiral organic compounds of pharmacological interest. These reactions include functionalisation reactions of aromatic and heteroaromatic compounds (Friedel-Crafts reactions), carbanion addition reactions (aldol reactions, Henry reactions), addition reactions of organometallic reagents (alkylation and alkynylation) or cycloaddition reactions (Diels-Alder reactions, 1,3-dipolar addition) etc. We have recently incorporated the use of photoredox catalysis in C-C bond formation reactions.
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- Desarrollo de nuevas metodologias de formacion de enlaces C-C mediante catalisis asimetrica
- Desarrollo de nuevos catalizadores quirales basados en complejos metalicos y organocatalizadores
- Sintesis enantioselectiva de compuestos de interes farmacologico y agroquimico utilizando catalisis enantioselectiva
- Desarrollo de nuevas metodologias de formacion de enlaces C-C mediante catalisis fotorredox.
- Development of new asymmetric catalytic methodologies for C-C bond formation.Use of chiral catalysts (metal complexes and organocatalysts) in new reactions of interest in organic synthesis in which C-C bonds and stereogenic centres are generated simultaneously. Synthesis of chiral building blocks.
- Development of new chiral catalysts.Design and synthesis of new chiral ligands capable of forming complexes with metal ions useful as chiral catalysts (Lewis acids). Design and synthesis of new chiral organic catalysts by proton transfer, hydrogen bridge formation or phase transfer.
- Enantioselective synthesis of products with biological and pharmacological interest.Enantioselective synthesis of compounds with known or potential biological or pharmacological activity by chemical transformation of chiral products obtained by asymmetric catalysis.
| Name | Nature of participation | Entity | Description |
|---|---|---|---|
| GONZALO BLAY LLINARES | Director | Universitat de València | |
| Research team | |||
| MARIA LUZ CARDONA PROSPER | Member | Universitat de València - Estudi General | UVEG honorary professor |
| JOSE RAMON PEDRO LLINARES | Member | Universitat de València | |
| CARLOS VILA DESCALS | Member | Universitat de València | |
| MARC MONTESINOS MAGRANER | Member | Universitat de València | |
| ALICIA MONLEON VENTURA | Member | Universitat de València | |
| AMPARO SANZ MARCO | Member | Universitat de València | |
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- Organic Chemistry
- Síntesis enantioselectiva; Friedel-Crafts; Alquilación; Alquinilación; Reacción de Henry; Reacciones de cicloadición
- ligandos quirales; metales de transición; organocatalizadores, ácidos de Lewis quirales; transferencia de protón; puente de hidrógeno; PTC
- Indoles; pirroles; heterociclos; aminoalcoholes; aril etanol aminas
