The UV research groups (GIUV) are regulated in the 1st chapter of the Regulation ACGUV48/2013, which explains the procedure for creating new research structures. They are basic research and organizational structures that result from the voluntary association of researchers that share objectives, facilities, resources and common lines of research. These researchers are also committed to the consolidation and stability of their activity, work in groups and the capability to achieve a sustainable funding.
The research groups included in the previously mentioned Regulation are registered in the Register of Research Structures of the Universitat de València (REIUV), managed by the Office of the Vice-principal for Research. The basic information of these organisms can be found in this website.
Participants
Data related to research groups featured in various information dissemination channels shall not, under any circumstances, imply a statement or commitment regarding the employment or academic affiliation of individuals associated with the Universitat de València. Their inclusion is solely the responsibility of the group directors. Updates will be made upon request from interested parties.
- Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)
Reference of the Group:
Description of research activity: Self-assembly of amphipathic molecules with lipid and polypeptide characteristics, natural or synthetic. Characterisation of membrane structures of biological, biomedical and biotechnological interest, with special interest in pore, fusion and fission structures. Light-induced molecular changes in membranes, natural or synthetic. Design, implementation and applications of molecular switches in membranes.
Web:
Scientific-technical goals: - Disseny i caracteritzacio de la interaccio amb membranes lipidiques de peptids i proteines amb activitat formadora de porus y remodelarora de membranas.
- Descripcio de mecanismes de formacio de porus, canvis de curvatura i processos de fusio i fissio de membranes.
- Determinants moleculars i propietats fisic-quimiques responsables a nivell de sequencia de de l'activitat en membranes de molecules polipeptdidicas.
- Redisseny de molecules polipeptidiques per al control de la seva activitat.
- Desenvolupament de nova metodologia, experimental i teorica, per a l'estudi estructural i funcional d'activitats de membrana.
Research lines: - Design and synthesis of membrane-active polipeptides.Design of new polypeptide sequences with membrane activity from native proteins and peptides. Methodologies: Computational analysis of polypeptide structures at various levels. Chemical synthesis of peptides.
- Biophysical characterization of polypeptide-membrane complexes in model systems.Study of the kinetic and thermodynamic properties of membrane-active complexes. Description of the structure of active complexes and their formation mechanisms. Methodology: infrared, UV-Vis, DC and fluorescence spectroscopies. Fluorescence microscopy. AFM nanoscopy. Langmuir monocaps. Molecular simulations. Theoretical diffusion models. Statistical analysis.
Group members:
CNAE:
Associated structure: - Institute of Molecular Science (ICMOL)
Keywords: - Pèptids membranoactius, dominios mínimos con actividad de membrana
- GUV, ATR-FTIR, Vesícula individual, Ley de Fick, Monocapas, Membranas soportadas
