BlockAce
Title: Multidisciplinary approach to blocking SARS-CoV-2 entry through antivirals and Decoy-ACE2 fragments
Research group: Viral Biology
This collaboration will employ a multi-disciplinary approach to identify inhibitors of SARS-CoV-2 receptor binding and entry. Combining expertise in medicinal chemistry, computational chemical biology, structural biology, and virology, 3 parallel approaches will be employed: (1) Immediate testing of compound libraries (>1,400) using a high-throughput cell assay for SARS-CoV-2 receptor binding and entry. (2) Computational screening and design, synthesis, and evaluation (3). Development of protein-based inhibitors derived from the ACE2 receptor. The final evaluation of hits for effectiveness and drug resistance will be done with SARS-CoV-2.
Total amount: 343.200 €
María-Jesús Pérez-Pérez (Instituto de Química Médica, IQM) and Ron Geller (Universitat de València)
- Jesús Rodríguez Díaz (Universitat de València)
- Sonsoles Martin Santamaría (Centro de Investigaciones Biológicas Margarita Salas, CIB)
- Alberto Marina Moreno, Vicente Rubio Zamora, Jerónimo Bravo Sicilia, José Luis Llacer Guerri (Instituto de Biomedicina de Valencia, IBV)
CSIC-CRUE-Santander
- Instituto de Química Médica, IQM
- Centro de Investigaciones Biológicas Margarita Salas, CIB
- Instituto de Biomedicina de Valencia, IBV