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The project proposes a new strategy for the screening of drugs and antibodies against the SARS-CoV-2 coronavirus. This is an innovative technology for drug screening that uses an affordable, fast, safe and efficient system to evaluate all types of antiviral compounds and antibodies that block the entry of SARS-CoV-2 virus into human cells. The use of recombinant viruses has been successfully used in drug screening for various medically important viruses, as well as in serological screening. The advantages of the proposal are well founded, highlighting that this technology may be applicable in the future to other viruses that constitute an emerging public health problem.
The main goal of this project is to define the effect of all possible mutations in a viral capsid, and to understand how different cellular and environmental pressures can alter the viability of such mutations in the capsid.
Cellular molecular chaperones are a group of conserved and abundant proteins that oversee protein folding and help maintain protein homeostasis. The goal of this project is to define all the chaperones and co-chaperones involved in the replication of respiratory syncytial virus, the single most important respiratory pathogen in children.
The main aim of this project was to define all the Hsp90 co-chaperones involved in the replication of respiratory syncytial virus, the single most important respiratory infection in infants.