The UV research groups (GIUV) are regulated in the 1st chapter of the Regulation ACGUV48/2013, which explains the procedure for creating new research structures. They are basic research and organizational structures that result from the voluntary association of researchers that share objectives, facilities, resources and common lines of research. These researchers are also committed to the consolidation and stability of their activity, work in groups and the capability to achieve a sustainable funding.
The research groups included in the previously mentioned Regulation are registered in the Register of Research Structures of the Universitat de València (REIUV), managed by the Office of the Vice-principal for Research. The basic information of these organisms can be found in this website.
Participants
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- Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)
Reference of the Group:
Description of research activity: In our group we design and synthesize ligands derived from the triazole ring and sulfonamide-type ligands, with which coordination compounds with different metal ions of biological interest [Cu(II), Zn(II), Fe(II,III),...] are prepared. The compounds are structurally and spectroscopically characterised. In a second stage, the interaction of the obtained complexes with DNA is studied, and their nuclease activity is tested with and without activating agents. In a new and current approach, the activity of the metallo-nucleases synthesised in combination with QDs (quantum dots) is studied, with the aim of achieving an enhancement and/or activation of their nucleolytic properties. The effect of photoactivation (with harmless light) on the compounds and on the nuclease-QDs systems is also investigated. Finally, the most active systems are tested in vivo on tumour cell lines. In parallel, the magnetic properties of the polynuclear compounds obtained are studied. In the case of cyclic trinuclear compounds, examples of spin-frustrated systems, a more exhaustive antisymmetric exchange study is carried out.
Web:
Scientific-technical goals: - Sintetizar nuevos compuestos capaces de reconocer selectivamente al ADN mimetizando el enlace ADN-proteina
- Obtener nuevas nucleasas oxidativas y/o hidroliticas; potenciar la actividad de las metalonucleasas mediante la combinacion con QDs (quantum dots)
- Ensayar los compuestos mas activos sobre lineas celulares tumorales con el fin de obtener farmacos alternativos en quimioterapia
- Evaluar la posible fotoactivacion de los sistemas QDs-metalonucleasas buscando una nueva generacion de farmacos para terapia fotodinamica
- Obtener compuestos con propiedades magneticas relevantes por inusuales y/o por presentar el fenomeno de canje antisimetrico
Research lines: - Chemical Nucleases based on Coordination Compounds.Our research basically consists of the preparation and characterisation of new oxidative and/or hydrolytic metallo-nucleases, mainly based on metal ion coordination compounds of biological interest with triazole-type ligands and sulfonamide-type ligands.
Group members:
CNAE:
Associated structure:
Keywords: - Nucleasa, interacción con el ADN, compuesto de coordinación, cobre, triazol, sulfonamida, magnetismo, canje antisimétrico, quantum dot
