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Laboratorio de Proteínas de Membrana - MemProt Lab

Referencia del grupo:

GIUV2013-167

 
Descripción de la actividad investigadora:
The purposes of our projects are to explore the mechanistic principles of membrane protein insertion, folding and assembly into lipid membranes and to investigate the factors that determine membrane protein stability. Our interest focuses on protein/protein-interactions relevant for maintaining tertiary and quaternary structure and function of integral membrane protein complexes. More specifically, we investigate the role of membrane-spanning domains, i.e. of transmembrane segments. The study is performed through an exhaustive investigation of glycophorin A as a model dimeric membrane protein, and from the knowledge of this system we try to understand the structure and function of the pulmonary surfactant SP-C protein, an extremely hydrophobic membrane protein. On the other hand, we are interested in the cell-to-cell transport of plant virus. This transport process is mediated by specialized viral movement proteins, which in same cases are membrane proteins, that drive the viral genome to the cellular membrane in order to be transported into neighbouring uninfected host cells through the plasmodesmal channel. We are currently investigating the targeting and the insertion...The purposes of our projects are to explore the mechanistic principles of membrane protein insertion, folding and assembly into lipid membranes and to investigate the factors that determine membrane protein stability. Our interest focuses on protein/protein-interactions relevant for maintaining tertiary and quaternary structure and function of integral membrane protein complexes. More specifically, we investigate the role of membrane-spanning domains, i.e. of transmembrane segments. The study is performed through an exhaustive investigation of glycophorin A as a model dimeric membrane protein, and from the knowledge of this system we try to understand the structure and function of the pulmonary surfactant SP-C protein, an extremely hydrophobic membrane protein. On the other hand, we are interested in the cell-to-cell transport of plant virus. This transport process is mediated by specialized viral movement proteins, which in same cases are membrane proteins, that drive the viral genome to the cellular membrane in order to be transported into neighbouring uninfected host cells through the plasmodesmal channel. We are currently investigating the targeting and the insertion mechanisms of these viral membrane proteins into the biological membranes.
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Objetivos cientificotécnicos:
  • Our Group focuses on basic aspects of the folding and assembly of proteins in lipid membranes.
 
Líneas de investigación:
  • Plegamiento de Proteínas de Membrana . Our goal is to explore the mechanistic principles of membrane protein insertion, folding and assembly into lipid membranes and to investigate the factors that determine membrane protein stability.
  • Proteómica de proteínas de membrana. Overexpression of membrane proteins is often essential for structural and functional studies, but yields are frequently too low. Therefore, we investigate the consequences of overexpression of different membrane proteins in search for new components to improve such yields.
 
Componentes del grupo:
Nombre Carácter de la participación Entidad Descripción
Ismael Mingarro MuñozDirector-a UVEG-Valencia Catedràtic-a d'Universitat
Equip d'investigació
Patricia Casino FerrandoMembre UVEG-Valencia Investigador-a contractat-ada Ramón y Cajal
María Jesús García MurriaMembre UVEG-Valencia Professor-a Ajudant-a Doctor-a
Luis Martínez GilMembre UVEG-Valencia Professor-a Ajudant-a Doctor-a
Manuel Mateo Sánchez del PinoMembre UVEG-Valencia Professor-a Contractat-da Doctor-a
Brayan Grau ArgenteCol·laborador-a UVEG-Valencia Investigador-a en Formació Atracció de Talent