The UV research groups (GIUV) are regulated in the 1st chapter of the Regulation ACGUV48/2013, which explains the procedure for creating new research structures. They are basic research and organizational structures that result from the voluntary association of researchers that share objectives, facilities, resources and common lines of research. These researchers are also committed to the consolidation and stability of their activity, work in groups and the capability to achieve a sustainable funding.
The research groups included in the previously mentioned Regulation are registered in the Register of Research Structures of the Universitat de València (REIUV), managed by the Office of the Vice-principal for Research. The basic information of these organisms can be found in this website.
Participants
Data related to research groups featured in various information dissemination channels shall not, under any circumstances, imply a statement or commitment regarding the employment or academic affiliation of individuals associated with the Universitat de València. Their inclusion is solely the responsibility of the group directors. Updates will be made upon request from interested parties.
- Registered groups in the Register of Research Structures of the Universitat de València - (REIUV)
Reference of the Group:
Description of research activity: La seua activitat se centra en les àrees de neurociència i investigació cardiovascular, sent els seus objectius principals l'estudi de la fisiologia de la circulació cerebral, la prevenció, fisiopatologia i tractament de l'ictus isquèmic, i la fisiopatologia de la vasculopatia diabètica, com a factor de risc cerebrovascular. Es realitza tant investigació preclínica (models animals d'ictus i diabetis) com a clínica (pacients de d'ictus).
Web:
Scientific-technical goals: - Fisiologia de la circulacion cerebral
- Fisiopatologia de la isquemia cerebral
- Neuroproteccion y neurorreparacion
- Diabetes y daño vascular
- Ictus isquemico agudo
Research lines: - Cellular senescence as a biomaker and therapeutic target in ischaemic stroke.Brain cell senescence remains unexplored as a target for neuroprotection in stroke. The aim is to characterise brain cell senescence associated with ageing and stroke in a rat model, and to reposition a senolytic drug, Navitoclax, as an effective neuroprotectant for use as an adjunct to endovascular treatment in ischaemic stroke. The influence of gender will also be analysed.
- Analysis of thrombi obtained by mechanical thrombectomy in patients with ischemic stroke due to large vessel occlusion.In patients with large vessel ischaemic stroke, the use of thrombectomy devices makes it possible to retrieve the occluding thrombus and make it available for analysis. The thrombus can be studied fresh, frozen or fixed for preservation and subsequent analysis. The aim is to subject thrombi to different types of analysis to obtain information on their characteristics, structure and composition, and to establish associations between the nature of the thrombus and clinical-radiological variables relating to the diagnosis, treatment and prognosis of stroke. It will also help to explain the behaviour of the thrombus during fibrinolysis and/or thrombectomy, enabling research and development of more effective thrombolytic treatments and thromectomy devices.
- Mitophagy and inflammation in cerebral ischemia: therapeutic target.Inflammation and loss of mitochondrial function are involved in the development of ischemic brain damage. Mitophagy (selective degradation of damaged or dysfunctional mitochondria by autophagy) is an essential homeostatic mechanism for maintaining a healthy mitochondrial population. There is evidence to suggest that mitophagy and inflammation may be related, and thus mitophagy could be a mechanism for regulating inflammation. The objectie is to characterize brain cell mitophagy and its relationship to inflammation in a rat model of cerebral ischemia.
- Microglial polarization towards M2 phenotype as a neuroprotective mechanism after ischemic stroke.Polarisation of microglia following a cerebrovascular accident towards an M2 or anti-inflammatory phenotype could be a neuroprotective mechanism. The objective is to characterise the polarisation process of microglia and explore the use of drugs that induce this polarising effect as an option for the treatment of ischemic strokes, in both normoglycemia and hyperglycemia conditions.
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CNAE:
Associated structure:
Keywords: - Ischaemic stroke, cellular senescence, neuroprotection
- Ictus isquémico, trombectomía, trombo cerebroarterial
- learning outcomes, teaching innovation, professional competences
- Neurología: manejo del ictus isquémico
